Importantly, our data support that the loss of STK4 in colon cancer is a good indicator of overall survival and disease survival, in agreement with Minoo group's finding [24]; STK4 defect results in the failure of β‐catenin phosphorylation and ubiquitination that may subsequently lead to β‐catenin accumulation and consequently result in colon cancer metastasis. The gene discussed is STK4; the disease is colonic neoplasm.