FAP‐expressing CAFs can modulate T cells in an NO‐dependent manner, their depletion resulting in increased CD8 T‐cell tumour infiltration [215], and podoplanin expressing CAFs cross‐presented tumour antigen in MHC I to directly induce antigen‐specific antigen‐dependent T‐cell deletion and anergy via PD‐L2 and Fas interactions [214]. This evidence concerns the gene PDCD1LG2 and neoplasm.