Here, CAF‐secreted factors such as hyaluronan [256], FGF, HGF and VEGF‐C directly induce lymphangiogenesis [257, 258, 259], while tumour‐derived lysyl oxidase‐like protein 2 (LOXL2) and sonic hedgehog have been reported to stimulate CAFs to upregulate VEGF‐C and SDF‐1α to support lymphatic expansion [260, 261]. The gene discussed is VEGFC; the disease is neoplasm.