The latter manifests as the disruption of trans-placental oxygenation, decreased blood flow, and imbalance between angiogenic placental growth factors and antiangiogenic proteins, such as VEGF, PlGF, sFlt-1, and sENG (van den Hooven et al. 2012), and then preeclampsia ultimately develops. The gene discussed is PGF; the disease is preeclampsia.