Of these nine participants in the intervention group, eight were detected as a result of a positive Cytosponge-TFF3 test and a subsequent endoscopy and have all undergone a curative intervention (seven participants underwent endoscopic therapies, and one participant underwent an oesophagectomy for a stage IB cancer involving the first layer of the submucosa; appendix p 133). The gene discussed is TFF3; the disease is cancer.