TFF3 and Barrett esophagus: We did this pragmatic, randomised controlled trial, involving patients with recurrent symptoms of gastro-oesophageal reflux who had been taking acid-suppressant medication prescribed by their general practitioner, to investigate whether the Cytosponge-TFF3 test, administered in the community setting, leads to the identification of more patients with Barrett's oesophagus than does usual clinical practice for endoscopy referral in England.