Participants with multi-site atherosclerotic plaques (compared with site <=1) had higher level of age, SBP, CF-PWV, FPG, CRP, HCY, UA, BUN, CR, and had higher proportion of CF-PWV > 12 m/s, male, CAD, stroke, PAD, hypertension, diabetes, dyslipidemia, smoking, alcohol, drugs of CVD, antidiabetic drug and lipid-lowering drug, and had lower BMI, DBP, TC, HDL-C and LDL-C. This evidence concerns the gene CRP and peripheral arterial disease.