F10 and viral infectious disease: Interestingly, we found the transcriptomic responses of R. philippinarum to LPS and PGN shared more DEGs, including C1qL, CTL, SRCR, CATH, coagulation factor X (FA10), Leucine-rich repeat-containing protein (LR74A), etc. This result might be due to both LPS and PGN are derived from bacteria (Gram-negative and Gram-positive, respectively), whereas poly(I:C) is a synthetic analog of dsRNA associated with viral infection [29].