Williams-Gray et al. [2] showed that serum levels of cytokines, such as IL-1β, TNF-α, and IL-10, are higher in PD patients than in age-matched non-PD controls; higher TNF-α levels are associated with faster rates of motor decline and higher IL-1β levels are associated with a faster rate of cognitive decline. The gene discussed is IL1B; the disease is Mental deterioration.