First, by combined analysis of the publically available ChIP-sequencing and RNA-sequencing data, we have identified cell-cell junction pathway may be the downstream of HNF4G that may promote PDAC cell invasion and metastasis although the ChIP-sequencing data were from hepatocellular carcinoma cells and therefore need confirmation in PDAC. The gene discussed is HNF4G; the disease is hepatocellular carcinoma.