GDF6 and Abnormality of the kidney: As the three GDF6 variant carriers were among these patients, 3 of 56 patients (5.4%) with renal plus skeletal, ocular, or auricular features carried GDF6 variants with a disease-causing prediction, a significant frequency increase compared with that in renal anomaly patients without abnormalities of the skeleton, eye, or ear (0/138, p = 0.0231, Fisher’s exact test).