CLOCK and early-onset autosomal dominant Alzheimer disease: CLOCK single nucleotide polymorphisms (SNPs) are associated with obesity, hyperglycemia and type 2 diabetes-associated cardiovascular diseases, Alzheimer’s disease and the quality of aging in a cohort of nonagenarians.17–21 Moreover, CLOCK deficiency leads to reduced lifespan and the occurrence of aging-associated pathologies, including cataracts and dermatitis, in mice.22 However, the molecular mechanisms and targets by which CLOCK regulates organismal aging remain largely unexplored.