Through WDD, we identified SMAD3 as an additional keratoconus-susceptibility gene (OR = 1.44 (1.16–1.80), P = 0.001), and CPLX2 as a future candidate gene for keratoconus-susceptibility (OR = 0.70 (0.46–1.05), P = 0.082). This evidence concerns the gene CPLX2 and keratoconus.