LRP6 and neuroblastoma: Since the iper-activation of the Wnt/β-catenin signal transduction pathway has been implicated in the maintenance or regulation of CSCs self-renewal, in tumorigenesis, and in activation of cancer cell dedifferentiation into CSCs57,58, we tested in NB cells the Roniciclib effect on the expression of β-catenin and of the Lipoprotein Receptor-related Protein-6 (LRP6), a transmembrane receptor essential for Wnt-induced signal transduction59, observing a strong decrease for both proteins (Fig. 5).