MYCN and neuroblastoma: We selected IMR-32, ACN and SH-SY5Y cell lines due to their different genomic characteristics: IMR-32 display MYCN (v-myc myelocytomatosis viral related oncogene, neuroblastoma derived) amplification, whereas ACN and SH-SY5Y do not, and SH-SY5Y exhibit strong c-MYC protein expression.