Mice immunised with (MS@OVAinMOF)@(anti-CTLA4inMOF) show the highest population of tetramer+CD8+ T cells in the spleen and tumour sites and the highest cytokine contents in the spleen (IFN-γ and TNF-α) among all the groups (Fig. 4). The gene discussed is IFNG; the disease is neoplasm.