The Fructose-Bisphosphatase 1 (FBP1) is a rate-limiting enzyme in gluconeogenesis, which is suppressed in kidney tumors and thus feeds ccRCC; FBP1 is associated with impaired cell proliferation, glycolysis and the pentose phosphate pathway in ccRCC in a catalytic-activity-independent manner via direct interaction with the HIF inhibitory domain18. Here, FBP1 is linked to kidney neoplasm.