Using the CMap database, we evaluated the co-upregulated genes in single-gene perturbation experiments in CRC, and found that disulfiram, and ciclopirox induce the expression of JUN;MT1X;NDRG1;FOSL1;DNAJB1;MT2A;HSPH1;MAFF;SERPINH1;MT1H;EPHA2;MT1E;HSPA1A (disulfiram) and JUN;MT1X;FOS;EIF1;RHOB;FOSL1;DNAJB1;ZFP36;MT2A;MAFF;MT1H;PHLDA2;MT1E (ciclopirox). This evidence concerns the gene EPHA2 and colorectal carcinoma.