CDK4 and colorectal carcinoma: Likewise, the drugs betaxolol, homatropine, clomifene, penbutolol, bisoprolol, atropine oxide, alpha-estradiol, propofol, prestwick, and arcaine were predicted to induce the expression of the top kinases involved in CRC (CSNK2A1, CDK1, MAPK14, CDK4, GSK3B, AKT1, and CDK2).