KEGG enrichment analysis for the co-upregulated genes in CRC vs the normal mucosa, prioritized the pathways “glycolysis/gluconeogenesis”, “pathogenic E. coli infection”, “IL-17 signaling pathway”, and “salmonella infection”; whereas the co-downregulated genes participated mainly in “ribosome”, “fatty-acid degradation”, “valine, leucine, and isoleucine degradation” and “ascorbate and aldarate metabolism”, agreeing with the above-mentioned GO terms (Fig. 2a, b and Supplementary Table 3). The gene discussed is IL17A; the disease is escherichia coli infection.