The co-upregulated genes in CRC are further enriched in “tertiary granule lumen”, “secretory granule lumen”, and “specific granule lumen” (GO cellular component); and “histone methyltransferase binding”, “GPI anchor binding”, and “MHC-II protein complex binding” (GO molecular function) (Fig. 1a and Supplementary Table 2). The gene discussed is PRDM9; the disease is colorectal carcinoma.