To further determine whether p65 mediates the metastasis of normoxic CRC cells induced by HSS CRC cell-derived IL-8, we applied chemicals that specifically inhibit p65, including LY2409881 and SC-51415,16, and dihydroartemisinin (i.e., DHA) and SN5017,18. The gene discussed is CXCL8; the disease is colorectal carcinoma.