Notably, CRC cells expressed less E-cadherin (decreased E-cadherin/b-actin ratio, E/A ratio) and more Vimentin (increased Vimentin/b-actin ratio, V/A ratio) when treated with the medium enriched in IL-8, and in the contrast when treated with the medium depleted of IL-8 (Fig. 4a). This evidence concerns the gene VIM and colorectal carcinoma.