In the present study, we found that IL-8 induced the phosphorylation of IKK2, IκB, and p65 and promoted EMT of normoxic CRC cells (Figs. 4a and 6b), and the inhibition of p65 attenuated the effects of IL-8 on normoxic CRC cells (Fig. 4b–g). Here, IKBKB is linked to colorectal carcinoma.