More interestingly, upon administration of bevacizumab via intratumoral injection, the tumor cells highly expressed GFP, HIF1α and IL-8 (Fig. 5b, c); and furthermore, a greater number of cells were GFP+ cells (Figs. 5d and S5D), suggesting that TBe were more hypoxic than TPBS. The gene discussed is HIF1A; the disease is neoplasm.