Therefore, novel curcumin derivatives that have been previously shown to neutralize or modulate preformed toxic recombinant TauO (48) were screened and tested against well-characterized disease-relevant tau oligomeric strains isolated from AD, DLB, and PSP brain homogenates (23, 49, –, 51, 64). The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.