MAPT and Alzheimer disease: As expected, no FRET-positive cells were observed with liposome vehicle or liposome in the presence of CL3 or untreated control (Fig. 8A), whereas cells transduced with AD, DLB, and PSP oligomeric tau seeds exhibited a significant increase of FRET-positive cells as shown by the bright green signals (Fig. 8, B–D), indicating intercellular tau inclusion formation.