In one study of 1128 patients with hypertension of whom 188 were taking ACE inhibitors/ARB,6 in-hospital use of ACE inhibitor or ARB medication was associated with a lower risk of all-cause in-hospital mortality (adjusted HR 0.42; 95% CI 0.19 to 0.92; p=0.03). This evidence concerns the gene ACE and hypertensive disorder.