There was no significant difference in sex distribution, prevalence of hypertension, use of antihypertensive drugs, systolic and diastolic BP, smoking status, total cholesterol, triglycerides, LDL cholesterol, BMI, hemoglobin, ESR, CRP, prevalence of pulmonary artery involvement and aortic regurgitation, and use of glucocorticoids, aspirin, and statins at the index date. The gene discussed is ESR1; the disease is Hypertension.