Perhaps the most potent of adipokines capable of initiating and promoting malignant transformation of breast epithelium is FGF2, essential for normal mammary gland development and stem cell function [39] yet a proven driver of various cancers and a target for new anti-cancer therapeutics [40], experimentally capable of inducing both skin and mammary epithelial cancers [31, 32]. This evidence concerns the gene FGF2 and cancer.