TMEM43 and breast cancer: After using a quantile normalization batch-correction procedure to integrate the two sets of normal breast transcriptome values, we used a two-dimensional visualization tool, TumorMap [19], to compare both the batch-specific and batch-integrated normal breast transcriptional landscapes to that of 1096 TCGA breast cancer samples spatially separated into their five different intrinsic subtypes (Fig. 1c): LumA, LumB, Her2, Normal-like, and Basal [20].