LOX and breast cancer: Since MM231 breast cancer cells cultured on TMG proliferated slower than they were on Matrigel [40] and secreted very less lactate to the medium (Fig. 6b), we speculate that LOX would only break down the limited amount of lactate under this situation and its inhibition of the cell proliferation on TMG would be similar to that of HUMEC on Matrigel (Fig. 6c).