Firstly, as for de novo DLBCL, NOS patients, the most frequently mutated genes were TP53 (28.9%), PIM1 (27.2%), KMT2D (25.9%), MYD88 (23.0%), and CD79B (22.6%) (Supplementary Fig. S1), and variant frequency of MYD88 was significantly more frequent compared with relapse DLBCL cases (P = 0.014). Here, MYD88 is linked to diffuse large B-cell lymphoma.