EZH2 and diffuse large B-cell lymphoma: By developing a subclassified algorithm based on coding region mutations, CN variations, and structure variations (SVs), they further identified four distinct genetic subtypes of DLBCL, which included BN2 (based on BCL6 fusions and NOTCH2 mutations), N1 (based on NOTCH1 mutations), MCD (based on the co-occurrence of MYD88L265P and CD79B mutations), and EZB (based on EZH2 mutations and BCL2 translocations).