In addition, for cases with single BCL6-trans signature, the mutations in several genes were also frequently determined in marginal zone lymphoma [31–33], including NOTCH2 (14.6%, 6/41), KLF2 (34.1%, 14/41), TNFAIP3 (19.5%, 8/41), and FAS (17.1%, 7/41) mutations. The gene discussed is NOTCH2; the disease is marginal zone lymphoma.