For cases with single BCL2-trans signature, a significant proportion (21/23, 91.3%) of cases harbor gene mutations in chromatin modification, including KMT2D, CREBBP, EP300, and EZH2, and several other signaling pathways (STAT6, SOCS1, TNFRSF14) which were similar to the genetic feature described in follicular lymphoma [30]. The gene discussed is CREBBP; the disease is follicular lymphoma.