Thirdly, through comparison of mutation gene pattern differences among GCB and non-GCB DLBCL subgroups in all de novo, relapsed, and transformed cases, we determined that the BCL2 translocation; the MYC translocation; and the CREBBP, TNFRSR14, BCL2, EZH2, SGK1, and ID3 mutations were significantly more frequent in GCB DLBCL (P < 0.001), whereas CD79B mutations, the MYD88L265P mutation, and the BCL6 translocation were more common in non-GCB DLBCL (P < 0.001) (Fig. 1a). Here, BCL6 is linked to diffuse large B-cell lymphoma.