Although several specific subgroups, such as primary DLBCL of the central nervous system (PCNSL), primary mediastinal (thymic) large B-cell lymphoma (PMBL), primary cutaneous DLBCL, leg type (PCDLBCL-LT), high-grade B-cell lymphoma, not otherwise specified (HGBL, NOS), and HGBL with MYC and BCL2 and/or BCL6 translocations (HGBL-DH/TH), are all well-defined entities, they share clinicopathologic features and genetic alterations with DLBCL, NOS according to previous studies [7–10]. This evidence concerns the gene BCL2 and high grade B-cell lymphoma.