Secondly, as for gene functional groups, mutations in genes associated with chromatin remodeling, including KMT2D and CREBBP, and genes associated with apoptosis resistance, including BCL2, were significantly enriched in cases of transformed follicular lymphoma (tFL) in comparison with de novo cases (P = 2.20 × 10− 4; P = 3.51 × 10− 4; P = 1.93 × 10− 5). The gene discussed is CREBBP; the disease is follicular lymphoma.