Therefore, we decided to seed our analysis from 5 genetic alterations which participated in the most important cellular signaling pathways in DLBCL pathogenesis, i.e. cellular proliferation (MYC translocation), apoptosis resistance (BCL2 translocation), immune cell differentiation abruption (BCL6 translocation) and activation of inflammation pathway (CD79B Y196 and MYD88 L265P). This evidence concerns the gene MYD88 and diffuse large B-cell lymphoma.