Three other transcripts upregulated in chronic neurodegeneration models encode for transcription factors: Gatad2b, Nr4a3, and Tsc22d1. Remarkably, GATA zinc finger domain containing 2B (GATAD2B) is a transcriptional repressor whose loss of function mutations have been associated with intellectual disability and synapse loss [85]. The gene discussed is NR4A3; the disease is Intellectual disability.