Recently, we reported that somatic ATM mutations in solid tumors (except brain tumors) were related to markedly improved responses after RT compared with tumors not harboring ATM mutations: an overall response rate of 61.0% (vs. 24.0% in ATM mut(−) tumors) with a durable response for a median period of 11 mo (vs. 3 mo in ATM mut(−)) [25]. Here, ATM is linked to brain neoplasm.