Isocitrate dehydrogenase (IDH)-wildtype high-grade glioma (diffuse astrocytoma, anaplastic astrocytoma, and glioblastoma multiforme [GBM]), being an aggressive brain tumor, has been correlated with poor prognosis despite the best trimodality treatment approaches (surgery, chemotherapy, and radiation therapy (RT)). Here, IDH3A is linked to central nervous system cancer.