WT1 methylation was significantly associated with the risk of luminal A subtype of breast cancer with multivariable adjusted OR of 2.61 (95% CI: 1.18–5.74, P = 0.02), and PS adjusted OR of 2.62 (95% CI: 1.11–6.20, P = 0.03). This evidence concerns the gene WT1 and breast carcinoma.