BRCA2 and female reproductive organ cancer: Most gynecological cancers are sporadic, but approximately 10–18% of OC has a hereditary pattern that attributed to mutations in one of the BRCA genes.8 BRCA1and BRCA2 mutations confer a lifetime risk for developing OC of 39–46 % and 11–27%, respectively.9 Other genes besides BRCA1 and BRCA2 are also related to ovarian cancer.10 Until their 70 years of age, women with Lynch syndrome have a 5–10% estimated risk for ovarian cancer.1 When the personal or family history suggests a high risk to hereditary ovarian-breast cancer predisposition, a geneticist should be consulted.