Recently, a large multi-centre genome wide association study (GWAS) in the United States analysing 2075 FECD patients and 3342 control subjects identified common polymorphisms in proximity to KANK4, LAMC1 and LINC00970/ATP1BP1, in addition to TCF4 (discussed below), that showed a significant association with increased FECD risk (Afshari et al., 2017). This evidence concerns the gene LAMC1 and Fuchs endothelial corneal dystrophy.