RAN and spinocerebellar ataxia type 8: RAN translation has been implicated in several repeat-mediated diseases including spinocerebellar ataxia 8 (SCA8) (Zu et al., 2011), C9ORF72 ALS/FTD (Ash et al., 2013; Mori et al., 2013; Zu et al., 2013), DM1 (Zu et al., 2017) and DM2 (Zu et al., 2017).