Thus, it is conceivable that the presence of RAN translated products originating from the CTG18.1 expansion sequence may contribute to, or drive, the accelerated levels of corneal endothelial cell death observed in FECD (Ayhan et al., 2018; Banez-Coronel et al., 2015; Zu et al., 2011). Here, RAN is linked to Fuchs endothelial corneal dystrophy.