CASP1 and Salmonella Infections: Phagocytes, such as macrophages, respond to Salmonella infection through inflammasome formation involving NLR family apoptosis inhibitory proteins (NAIP)2 or NAIP, and NLRs such as NLRC4 and NLRP3 (Franchi et al., 2009; Miao et al., 2010), which activate caspase-1 (Zhang et al., 2015).