CASP1 and Salmonella Infections: Instead, Gsdmd–/–;Casp8–/–;Ripk3–/–;Bax–/–;Bak–/– iBMDMs still died upon Salmonella infection, containing cleaved caspases-3 and -7 (Figures 5A and 5B), indicating that the combined absence of BAX and BAK could be compensated for by rewiring the cell in a manner that allowed for caspase-1 to trigger the executioner caspases-3 and -7 independently of MOMP.