CASP1 and infection: However, at week 3 post-infection, Casp1–/–;Casp11–/–;Casp12–/– and Casp1–/–;Casp11–/– mice presented with similar bacterial titers that were slightly higher compared to those observed in WT controls (Figure 1B), revealing that caspase-12 did not play a critical role in bacterial clearance by compensating for the combined absence of caspases-1 and -11.