CASP12 and infection: However, 6 h after infection with Salmonella, a substantial fraction of Casp1–/–;Casp11–/– and Casp1–/–;Casp11–/–;Casp12–/– BMDMs had died (Figure 2A), reiterating that caspase-12 was not critical for the response to Salmonella infection.