CASP3 and Salmonella Infections: Ablating this alternative cell death circuit by deleting caspases-3 and -7 was yet again not sufficient to prevent cell death, as Gsdmd–/–;Casp8–/–;Ripk3–/–;Casp3–/–;Casp7–/– iBMDMs still died upon Salmonella infection, although this occurred with slower kinetics and lower efficiency compared to Gsdmd–/–;Casp8–/–;Ripk3–/–;Bax–/–;Bak–/– iBMDMs (Figure 5C).