CASP1 and Salmonella Infections: We also noted in these experiments that Casp1–/–;Casp11–/–;Casp12–/– iBMDMs showed more prominent processing of caspase-8 following Salmonella infection compared to WT iBMDMs and that this was accompanied by classical markers of apoptosis, such as cleavage of BID and caspases-3, -7, and -9 (Figures 2B and 3B).