These findings indicate that although caspase-8 was dispensable for the early pyroptotic cell death upon Salmonella infection, caspase-8-driven apoptosis, rather than caspase-8-mediated pyroptosis or RIPK3- and MLKL-driven necroptosis, was responsible for the delayed type of cell death observed in Casp1–/–;Casp11–/–;Casp12–/– BMDMs. The gene discussed is MLKL; the disease is Salmonella Infections.