CASP1 and infection: Consistent with earlier reports using WT strains of S. Typhimurium (Broz et al., 2012), we observed slightly elevated bacterial titers in Casp1–/–;Casp11–/– mice 3 weeks post-infection compared to WT controls (Figure 1A), but the lack of pyroptosis did not affect their capacity to clear the bacteria by 12 weeks post-infection.