Interestingly, the short-lived gene group included several Krüppel-like transcription factors (KLF3, KLF6, KLF9, KLF11) and zinc finger transcriptional factors involved in lymphocyte homeostasis (41) and viral infection (KEGG pathway, https://www.genome.jp/kegg/). The gene discussed is KLF11; the disease is viral infectious disease.