Both CD4 and CD8 T cells showed similar frequency in WT and IL16 KO mice after MHV68 infection (Fig 8A and 8B), however, IFN-γ-expressing Th1 subset of CD4 T cells and CD44+ activated CD4 T cells were dramatically increased in IL16 KO mice as compared to WT mice (Fig 8C and 8D). Here, CD8A is linked to infection.