MAPT and early-onset autosomal dominant Alzheimer disease: Some examples that lend support to this possibility relate to hallmarks of Alzheimer’s disease that has a known association with liver dysfunction, such as brain tau secretion and its presence in the CSF as well as clearance of toxic accumulations of brain amyloid-beta (Pernègre et al., 2019; Bacyinski et al., 2017; Nho et al., 2019); however the link between the brain secretion or drainage and liver disruption is yet unclear.