So, increased level of NT‐proBNP is a marker of: (a) high‐pressure load from refractory hypertension (also increased by pain) and strain on the left ventricle, (b) heart failure from severe aortic regurgitation in type A AAD, (c) renal dysfunction due to its decreased excretion from the kidney, and (c) inflammation, which altogether may contribute to poor prognosis in aortic dissection patients.6, 7. Here, NPPB is linked to heart failure.