NPPB and aortic valve insufficiency: So, increased level of NT‐proBNP is a marker of: (a) high‐pressure load from refractory hypertension (also increased by pain) and strain on the left ventricle, (b) heart failure from severe aortic regurgitation in type A AAD, (c) renal dysfunction due to its decreased excretion from the kidney, and (c) inflammation, which altogether may contribute to poor prognosis in aortic dissection patients.6, 7