Selected miRNAs including miR-27a, miR-34a, miR-128, miR-145, miR-150, and miR-335 may act as tumor suppressors, because they have already been associated with direct or indirect regulation of NANOG expression and epithelial-mesenchymal transition regulation in various cancers [8, 26, 29, 30, 34, 37–44]. The gene discussed is NANOG; the disease is cancer.