Hyperlipidemia activates the congenital and adaptive immune response by activating Toll receptor 2 (TLR-2) and TLR-4 pathways, resulting in the occurrence of inflammation and the expression of atherosclerosis-promoting genes in macrophages and endothelial cells, which can be of huge impact in the process of inducing atherosclerosis [3]. This evidence concerns the gene TLR4 and atherosclerosis.