TSP-1 in atherosclerosis is involved in multiple processes, including the migration of vascular smooth muscle and the degradation of matrix metalloproteinase 2 (MMP-2), basement membrane, and extracellular matrix, increasing the expression of cell adhesion factors and promoting monocyte recruitment to the vascular wall and migration to the subintima [25]. The gene discussed is THBS1; the disease is atherosclerosis.