In breast cancer, CircANKS1B can use miR-148a-3p and miR-152-3p to increase the expression of the transcription factor USF1, thereby upregulating the expression of TGF-β1, which in turn activates TGF-β1/Smad signaling to promote epithelial-mesenchymal Transformation (EMT), thereby promoting the invasion and metastasis of breast cancer [11]. This evidence concerns the gene TGFB1 and breast cancer.