Compared with the adjacent tissues, the expression of circ-ITCH in esophageal squamous cell carcinoma is usually lower, and the high expression of circ-ITCH can sponge miR-214, miR-7, and miR-17, increase the level of ITCH, promote the degradation of ubiquitin and phosphorylated Dvl2, and finally inhibit the Wnt signaling, thus suppressing the tumor occurrence and development [10]. This evidence concerns the gene ITCH and neoplasm.