In the present study, we have shown that the expression of PAQR7, PAQR8, PAQR5, and PAQR6 genes is downregulated in the eutopic endometrium of patients with endometriosis compared to that of controls, which in turn could be associated with the progesterone resistance that leads to a reduced implantation capacity and increased risk of pregnancy loss observed in these patients [6]. The gene discussed is PAQR5; the disease is endometriosis.