The consistent decrease in mRNA levels of genes encoding mPRs and PGRMCs in the eutopic endometrium of women with endometriosis suggests a probable role of plasma membrane progesterone receptors in the pathogenesis of the disease, which should be addressed in future functional studies since it has been proposed that endometriosis originated from eutopic endometrium cells [38]. This evidence concerns the gene PGR and endometriosis.