In contrast, functional Smurf2 inhibits cancer cell proliferation and tumorigenesis via ubiquitination and degradation of several critical cellular proteins, such as Sirtuins (Yu et al., 2020), SIRT1 (Yu et al., 2019), ChREBP (Li et al., 2019), and RNF20 (Manikoth Ayyathan et al., 2020). This evidence concerns the gene SMURF2 and cancer.