IL1A and breast cancer: As shown in Figure 6, the ratio between CD8+ T cells versus Treg cells (Pwilcox.test = 0.0012, Rspearman = −0.23), the ratio between immune stimulation molecular (IFN-γ,IL-1A, IL-1B, and IL-2) versus immune suppression molecular (IL-4, IL-10, IL-11, and TGFB1) (Pwilcox.test = 0.0039, Rspearman = −0.14), and the ratio between Th17 cells versus Th2 cells (Pwilcox.test < 0.0001, Rspearman = −0.15) were significantly different between the two risk groups and negatively correlated with the methylation risk of BC patients.