APOE and atherosclerosis: GC-1 is also active in preventing atherosclerosis by lowering the levels of cholesteryl esters in the vasculature, as demonstrated in a model of Apolipoprotein E (Apo-E) deficient mice (56, 78), and is effective in stimulating the brown adipose tissue (BAT) thermogenesis, thus reducing fat mass [(79); Table 1].