Using CRISPR screen, Huang et al. validated that POU2F3 is an essential transcription factor in a subset of SCLC and POU2F3+ SCLC cells express the markers of tuft cell lineage, such as TRPM5, SOX9, CHAT, ASCL2, and AVIL. The gene discussed is TRPM5; the disease is small cell lung carcinoma.