While the use of immune checkpoint inhibitors alone may favor the cytolytic activity of immune cells that are present within the cancer mass, their combination with TGF-β pharmacological inhibitors may increase the infiltration of these cells in “cold tumors.” More details about the synergism between TGF-β pharmacological inhibitors and immune checkpoint inhibitors has been reviewed and discussed by others regarding its use in pre-clinical models and clinical trials (Ganesh and Massagué, 2018; Bai et al., 2019; Groeneveldt et al., 2020; Lind et al., 2020). The gene discussed is TGFB1; the disease is cancer.