For instance, treatments with 1D11 or 2G7 (monoclonal anti-TGF-β antibodies) were shown to reduce the metastatic burden and angiogenesis in breast cancer models and further experiments associated these results to an increased cytotoxicity exhibited by natural killer (NK) cells (Arteaga et al., 1993; Ganapathy et al., 2010; Biswas et al., 2011). Here, TGFB1 is linked to breast carcinoma.