BDNF and amyloidosis: For instance, using a transgenic model of amyloidosis in vivo, the team led by Prof. M.H. Tuszynski has shown that viral delivery of BDNF gene after the beginning of pathological processes development restrains the loss of synapses, partially normalizes the aberrant expression of the Aβ gene, improves synaptic transmission and restores learning and memory (Nagahara et al., 2009).