A string of recent reports suggest that BRG1 can modulate specific transcription events in endothelial cells to promote the pathogenesis of atherosclerosis (Fang et al., 2013), pulmonary hypertension (Chen et al., 2013), cardiac ischemia-reperfusion injury (Zhang et al., 2018c), and abdominal aortic aneurysm (Zhang et al., 2018b); in each of these cases, BRG1 deficiency in endothelial cells is invariably mirrored by compromised recruitment of circulating immune cells. The gene discussed is SMARCA4; the disease is pulmonary arterial hypertension.