Subsequently, 19 of the 40 ferroptosis-related genes were selected in glioma patients (SAT1, ATP5G3, FANCD2, HSPB1, HMGCR, CBS, GCLC, GCLM, CD44, ALOX12B, ALOX5AP, CISD1, NFE2L2, EMC2, ALOX5, DPP4, AKR1C2, LPCAT3, and NCOA4, P < 0.0001). The gene discussed is AKR1C2; the disease is central nervous system cancer.