In previous work from our group, we demonstrated that bacterial produced azurin is able to interfere with pro-tumorigenic and proliferative signaling pathways FAK, Src, and AKT, by attenuating the phosphorylation levels of these proteins in lung (Bernardes et al., 2016) and breast cancer cell lines (Bernardes et al., 2013). This evidence concerns the gene AKT1 and breast cancer.