Another approach is the use of MSC to deliver tumor cytotoxic agents such as TRAIL (TNF-α related apoptosis inducing ligand) (Grisendi et al., 2010; Loebinger et al., 2010; Deng et al., 2014; Yan et al., 2014; Xia et al., 2015; Rossignoli et al., 2019; Spano et al., 2019), osteoprotegerin (OPG) (Qiao et al., 2015), NK4 (Kanehira et al., 2007), and HGF (Zhu et al., 2009). Here, TNFRSF11B is linked to neoplasm.