For instance, CST3 increases neuron viability by inhibiting autophagy and cathepsin B (Cat B) in Cu/Zn-superoxide dismutase (SOD1)-mutant, or cytotoxicity-exposed neuroblastoma cell lines and primary cultured motor neuronal cells (Tizon et al., 2010; Watanabe et al., 2014). Here, CST3 is linked to neuroblastoma.