CST3 and amyotrophic lateral sclerosis: Recently, CST3 has also emerged as a potential neuron protector in neurodegenerative diseases like Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) (Mathews and Levy, 2016; Zou et al., 2017; Watanabe et al., 2018).