Here, we utilized a recombinant vesicular stomatitis virus expressing SNV glycoprotein precursor (rVSVΔG/SNVGPC), which has shown efficacy against SNV and ANDV in Syrian hamster models of infection (Warner et al., 2019b), to determine if vaccination of deer mice, either orally or intramuscularly, could prevent subsequent infection with SNV. The gene discussed is ART4; the disease is infection.