We next measured whether cyst burdens in the brain were maintained better when NK cells were depleted because as previously published, cyst numbers decrease in the brain as the parasite reactivates due to immune exhaustion and rescuing exhausted CD8+ T cells with anti-PDL1 maintains higher cyst numbers in the brains (Bhadra et al., 2011a,b, 2012, 2013). The gene discussed is CD8A; the disease is cyst.