CD8A and neoplasm: As for the changes in the density of CD8+TILs after treatment, univariate analysis revealed that patients in H-ΔCD8 group obtained shorter OS and DFS compared with patients in L-ΔCD8 group, which might be because the density of CD8+TILs significantly increased after neoadjuvant therapy was associated with poor clinical tumor staging III/IV (0.019).