Here, for the first time, we had used siRNA fragments to provide a mechanism that linked ELAVL1 with phospholipid remodeling, proving ELAVL1 was involved in the overexpression of LPCAT2, which further catalyzed the conversion of LPC (16:0) to PC (16:0/18:1) in esophageal cancer cells. This evidence concerns the gene LPCAT2 and esophageal cancer.